Das neu zugelassene Epilepsiepräparat Retigabin wurde vom Markt genommen.
Informationen hierzu finden sie im nachfolgenden Artikel.
„Zitat“
Gemeinsame Stellungnahme der Deutschen Gesellschaft für Epileptologie e. V. (DGfE) und der Deutschen Gesellschaft für Neurologie (DGN)Epilepsie: Neues Medikament mit innovativem Wirkmechanismus (Retigabin) ohne „Zusatznutzen“ eingestuft
Firma GSK nimmt Retigabin vorläufig in Deutschland vom Markt Die Deutsche Gesellschaft für Neurologie (DGN) und die Deutsche Gesellschaft für Epileptologie (DGfE) sehen die Notwendigkeit, die Behandlungskosten bei neu eingeführten Medikamenten in einem wirtschaftlichen Rahmen zu halten und befürworten dies uneingeschränkt. Das Ergebnis der Nutzenbewertung von Retigabin zeigt jedoch, dass viele besondere Aspekte der individuellen Behandlung von Epilepsiepatienten nicht ausreichend berücksichtigt wurden und daraus eine für die DGN und DGfE unverständliche Einschätzung resultierte. (Siehe auch die Stellungnahme der DGfE vom 7.3.2012 [3].) „Wir möchten gerne im Interesse der von Retigabin profitierenden Patienten einen gemeinsamen Lösungsansatz finden, da aus unserer Sicht ein gut belegbarer Zusatznutzen gegeben ist und dieser anerkannt werden sollte“, betont Professor Dr. Holger Lerche aus Tübingen, erster Vorsitzender der DGfE. „Unser Gesundheitssystem muss es sich leisten können, diesen Patienten mit einer schweren Erkrankung sinnvolle innovative Therapiealternativen anzubieten“, so die Meinung von Prof. Dr. Wolfgang H. Oertel, 1. Vorsitzender der DGN. Dialog des G-BA mit den Fachverbänden sinnvoll Die DGfE und die DGN möchten mit dem G-BA gerne in einen Dialog treten, um die Besonderheiten der Behandlung von Epilepsiepatienten – generell und aktuell im Hinblick auf Retigabin – zu erörtern und um eine gemeinsame Lösung zu erarbeiten. „Wir wollen vermeiden, dass Retigabin aufgrund einer international noch nie in ähnlicher Form da gewesenen Preisbildung in Deutschland dauerhaft vom Markt genommen wird und Patienten, die von Retigabin derzeit oder künftig profitieren können, diese innovative Substanz vorenthalten wird“, betont Dr. Thomas Mayer, erster Geschäftsführer der DGfE. Dies gilt in gleichem Maße für zukünftig zu erwartende Markteinführungen innovativer Medikamente. „Es besteht die Gefahr, die für den Standort wichtige Vorreiterrolle von Deutschland bei klinischen Studien und bei der Einführung von Medikamenten durch solche Maßnahmen aufs Spiel zu setzen“, so Prof. Dr. Wolfgang H. Oertel, 1. Vorsitzender der DGN. Nachgewiesene Anfallsfreiheit In den klinischen Studien zur Zulassung von Retigabin wurde ein Zusatznutzen durch die Anfallsfreiheit bei bis zu 8 Prozent der Patienten oder eine mindestens 50-prozentige Reduktion der Anfallsfrequenz bei etwa 30 Prozent der Patienten nachhaltig belegt [4]. Ein zusätzlicher Nutzen entsteht, indem erhebliche indirekte Kosten durch eine therapierefraktäre Epilepsie sowie die Verbesserung der Lebensqualität und der sozioökonomischen Situation der Patienten vermieden werden. Gewählte Vergleichstherapie fragwürdig Die Nutzenbewertung von Retigabin erfolgte gegenüber Lamotrigin bzw. Topiramat. Beide Präparate sind sowohl zur Mono- als auch zur Zusatztherapie bei fokalen und generalisierten Epilepsien bei Erwachsenen und Kindern (altersabhängig) zugelassen und verfügen somit über ein wesentlich größeres Zulassungsgebiet [6]. Lamotrigin ist ein Mittel der ersten Wahl als Monotherapie und wird für eine völlig andere Patientenklientel eingesetzt als Retigabin. Retigabin wurde erst vor kurzem zugelassen und wird auch von der DGfE und der DGN nicht als First-Line-Zusatztherapie gesehen, sondern nur dann, wenn initiale Monotherapien nicht erfolgreich waren und etablierte Zusatztherapien ebenfalls gescheitert sind, zu denen Topiramat zu zählen ist. Lamotrigin und Topiramat entsprechen deshalb nicht den Anforderungen einer zweckmäßigen Vergleichstherapie. Zudem waren die Zulassungsbedingungen für beide Substanzen 1993 bzw. 1998 völlig andere und die durchgeführten Studien sind deshalb nicht gut vergleichbar. Sinnvoll wäre der Vergleich mit einem Arzneimittel, das wie Retigabin erst kürzlich als Zusatztherapie bei fokalen Epilepsien bei Erwachsenen zugelassen wurde. Literatur
Deutsche Gesellschaft für Epileptologie e.V. Pressestelle der Deutschen Gesellschaft für Neurologie e.V. |
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